منابع مشابه
60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective.
Many important fields of research had a humble origin. In the distant past, A J P Martin's discovery that amino acids could be separated by paper chromatography and Moore and Stein's use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened the door to reveal the essential relationshi...
متن کاملKinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme.
The kinetics of the previously reported paired basic residue-specific pro-opiomelanocortin-converting enzyme from bovine pituitary intermediate lobe secretory vesicles (Loh, Y. P., Parish, D.C., and Tuteja, R. (1985) J. Biol. Chem. 260, 7194-7205) were studied using human 125I-beta-lipotropin as substrate. The enzyme, at a concentration of 20 ng/100 microliters cleaved human beta-lipotropin to ...
متن کاملStructure and regulation of the messenger RNA coding for the corticotropin /beta-lipotropin precursor.
We cyclized pyruvyl-L-Ala-L-Hmb-L-Tyr-NH, by treatment with liquid H F and obtained cyclo(-Hy Ala-L-Ala-L-Hmb-LTyr-) (compound 4) in good yield instead of the desired cyclic peptide containing the AAla residue (Noda et al., 1980). The possibility of converting the HyAla residue in compound 4 into a AAla residue is now under investigation. (b) The relationship between structure and activity of A...
متن کاملOne-pot total chemical synthesis of human α-synuclein.
Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
متن کاملOne-pot total chemical synthesis of human a-synuclein†
The misfolding and aggregation of the 140-residue neuronal protein a-synuclein (a-syn) play central roles in the pathogenesis of Parkinson’s disease (PD). Histologically, PD is defined post-mortem by the presence of intracellular proteinaceous inclusions known as Lewy bodies (LBs), composed mainly of insoluble a-syn amyloid fibrils. Several post-translational modifications (PTMs) have been iden...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.6.1556